A multi-peptide ANTI-AGE face cream with phytoestrogens and growth factors, developed for targeted correction of the signs of hormonal skin aging during peri- and postmenopause. The formula addresses decreased dermal density and elasticity, deepening wrinkles, facial contour deformation, age-related hyperpigmentation, dryness, and dull complexion.
The cream acts on the key mechanisms of age-related skin changes: it supports estrogen-dependent processes in the dermis, stimulates the synthesis of collagen, elastin, and glycosaminoglycans, strengthens the dermal-epidermal junction, and reinforces the skin’s internal structural framework. The multi-peptide system and growth factors modulate chronic low-grade inflammation and glycation, activate reparative mechanisms, improve microcirculation, and enhance oxygen exchange in tissues.
The formula simultaneously targets melanogenesis and melanin transfer, contributing to the correction of age-related hyperpigmentation and evening of the overall skin tone. Skin color uniformity increases, while dullness and a "sallow" appearance are visibly reduced.
The cream’s texture provides intensive hydration and restoration without a heavy feel, strengthens the skin barrier, and reduces transepidermal water loss. With regular use, the skin becomes denser and more resilient, wrinkles and expression lines are reduced, facial contours appear more structured, the complexion more even, and the skin texture visibly smoother and rejuvenated.
Red clover extract with a high concentration of phytoestrogens; restores skin density and elasticity, smooths wrinkles, and effectively slows hormonal aging processes.
Activates neoangiogenesis (formation of new blood vessels), improves tissue oxygenation and nourishment, provides powerful DNA protection and regeneration of skin cells. Effectively suppresses chronic inflammation and glycation, activating repair and rejuvenation mechanisms at the genetic level.
Provides strong protection against chronic inflammation and oxidative stress, suppressing premature aging factors. Stimulates regeneration and cellular renewal, increasing elasticity and density of the dermal matrix.
Activates collagen, elastin, and glycosaminoglycan synthesis, deeply restoring skin structure and internal volume. Intensively corrects age-related changes, smooths wrinkles, and visibly strengthens facial contours.
Targeted inhibition of the MITF transcription factor, blocking tyrosinase activity at the genetic level and reducing melanin synthesis. Deep correction of age-related hyperpigmentation, prevention of new pigment spot formation, and evening of overall skin tone.
Powerful activation of adhesion and communication mechanisms within the dermal–epidermal junction, significantly strengthening the basal membrane. Restores intercellular communication, improves firmness, delivers a lifting effect, and provides visible skin rejuvenation.
Targeted stimulation of keratinocyte and fibroblast proliferation and differentiation, regulation of the cell cycle, and acceleration of epidermal regeneration. Restores damaged epidermal areas, improves barrier function, and accelerates metabolic and restorative processes in the skin.
- Skin with signs of hormonal aging (menopause and postmenopause): decreased density, firmness, turgor, and elasticity.
- Chronic skin inflammation associated with structural deterioration and premature aging.
- Deep wrinkles and pronounced age-related changes: folds, loss of facial contour definition.
- Reduced regenerative capacity requiring intensive cellular renewal and deep restoration.
- Dull, atonic skin with visible oxidative stress and chronic fatigue.
- Dry, dehydrated skin with a compromised epidermal barrier.
- Comprehensive prevention and correction of age-related changes, especially hormonally driven.
- Pronounced age-related and hormonal hyperpigmentation via effective melanogenesis inhibition (Oligopeptide-68).
- Advanced aging of the neck and décolleté: loss of tone and elasticity, horizontal wrinkles (“Venus rings”), laxity related to hormonal aging.
- Pronounced reduction of inflammatory and oxidative processes, visible improvement in firmness and tone through normalization of dermal cell and vascular function (Palmitoyl Tetrapeptide-7).
- Comprehensive reconstruction of the dermal matrix, increased skin density and elasticity through collagen and elastin synthesis activation, deep wrinkle smoothing, and restoration of facial contour definition (Palmitoyl Tripeptide-1).
- Targeted gene-level pigmentation correction: effective lightening of existing age spots and strong prevention of new hyperpigmentation (Oligopeptide-68).
- Intensive cellular regeneration and tissue repair via activation of new vessel formation and improved microcirculation, enhancing skin resilience to aging and damage (Copper Tripeptide-1).
- Structural reinforcement and powerful lifting effect through restoration of intercellular connections and skin integrity (Hexapeptide-11).
- Effective counteraction of hormonal aging via phytoestrogen-rich red clover extract, increasing skin turgor, density, and elasticity (Trifolium Pratense Flower Extract).
- Accelerated epidermal regeneration and deep barrier restoration through growth factors, restoring smoothness, freshness, and healthy radiance (Oligopeptide-1, -2, -3).
AQUA (WATER), GLYCERIN, PENTYLENE GLYCOL, COPPER TRIPEPTIDE-1, PALMITOYL TETRAPEPTIDE-7, PALMITOYL TRIPEPTIDE-1, OLIGOPEPTIDE-68, HEXAPEPTIDE-11, OLIGOPEPTIDE-1, OLIGOPEPTIDE-2, OLIGOPEPTIDE-3, TRIFOLIUM PRATENSE (CLOVER) FLOWER EXTRACT, CHENOPODIUM QUINOA SEED EXTRACT, SALVIA SCLAREA (CLARY) EXTRACT, ALBIZIA JULIBRISSIN BARK EXTRACT, UNDARIA PINNATIFIDA EXTRACT, BACILLUS/SOYBEAN FERMENT EXTRACT, SIGESBECKIA ORIENTALIS EXTRACT, GLYCERYL STEARATE, SIMMONDSIA CHINENSIS (JOJOBA) SEED OIL, BUTYROSPERMUM PARKII (SHEA) BUTTER, OLUS OIL (VEGETABLE OIL), JOJOBA ESTERS, COCO-CAPRYLATE/CAPRATE, CETEARYL ALCOHOL, MICROCRYSTALLINE CELLULOSE, BUTYLENE GLYCOL, HELIANTHUS ANNUUS (SUNFLOWER) SEED WAX, POLYGLYCERYL-6 LAURATE, POLYGLYCERYL-10 OLEATE, DIMETHICONE, HYDROGENATED VEGETABLE OIL, SODIUM STEAROYL GLUTAMATE, CELLULOSE GUM, SOY ISOFLAVONES, GLYCOSPHINGOLIPIDS, ACETYL GLUTAMINE, ACETYL CYSTEINE, LECITHIN, HYDROGENATED LECITHIN, TOCOPHEROL, GLYCINE SOJA (SOYBEAN) OIL, ACACIA DECURRENS FLOWER WAX, CANDELILLA CERA (CANDELILLA WAX), SORBITAN PALMITATE, STEARETH-20, POLYGLYCERIN-3, XANTHAN GUM, SODIUM PHYTATE, CITRIC ACID, SODIUM CITRATE, SODIUM HYALURONATE, FOLIC ACID, CHRYSIN, BIOTIN, CAPRYLYL GLYCOL, PHENOXYETHANOL, CHLORPHENESIN, ETHYLHEXYLGLYCERIN, PARFUM (FRAGRANCE), O-CYMEN-5-OL, 1,2-HEXANEDIOL, N-HYDROXYSUCCINIMIDE, CHLORHEXIDINE DIGLUCONATE, SODIUM BENZOATE, POTASSIUM SORBATE, SODIUM OLEATE, DISODIUM EDTA
Apply the cream daily, morning and evening, to cleansed skin of the face, neck, and décolleté. Distribute evenly with light massage movements until fully absorbed before applying skincare or makeup. For stable anti-age results, include the cream in your daily routine.
RECOMMENDED CARE
FREQUENTLY PURCHASED WITH
19.9%
Wrinkle depth reduced by 19.9%
32.9%
Wrinkle density reduced by 32.9%
15.5%
Skin firmness increased by 15.5%
One of the most powerful complexes in this cream is the innovative Matrixyl® 3000 peptide complex, combining Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, with clinically proven efficacy.
Clinical studies conducted by Sederma involved over 50 women aged 51–72. Over 56–60 days of twice-daily use, results confirmed a reduction in wrinkle depth, density, and volume, along with increased skin firmness and elasticity.
Clinical studies conducted by Sederma involved over 50 women aged 51–72. Over 56–60 days of twice-daily use, results confirmed a reduction in wrinkle depth, density, and volume, along with increased skin firmness and elasticity.
CLINICAL STUDY RESULTS
KEY ACTIVE INGREDIENTS
TRIFOLIUM PRATENSE (CLOVER) FLOWER EXTRACT
Red clover extract with a high concentration of phytoestrogens; restores skin density and firmness, smooths wrinkles, and effectively slows hormonally driven skin aging.
Palmitoyl Tetrapeptide-7
Provides strong protection against chronic inflammation and oxidative stress, suppressing key factors of premature aging. Stimulates regeneration and cellular renewal while enhancing elasticity and density of the dermal matrix.
Copper Tripeptide-1
Activates neoangiogenesis (formation of new blood vessels), improves tissue oxygenation and nutrient supply, and provides powerful protection and regeneration of skin cell DNA. Effectively suppresses chronic inflammation and glycation while activating repair and rejuvenation mechanisms at the genetic level.
Oligopeptide-68
Targeted inhibition of the MITF transcription factor and tyrosinase activity at the genetic level, reducing melanin synthesis. Provides deep correction of age-related hyperpigmentation, prevents the formation of new dark spots, and evens overall skin tone.
Hexapeptide-11
Powerfully activates adhesion and communication mechanisms of the dermal–epidermal junction, significantly strengthening the skin’s basement membrane. Restores intercellular interaction, improves firmness, delivers a lifting effect, and provides visible skin rejuvenation.
PEPTIDE GROWTH FACTORS COMPLEX
(Oligopeptide-1, -2, -3)
(Oligopeptide-1, -2, -3)
Targeted stimulation of keratinocyte and fibroblast proliferation and differentiation, regulation of the cell cycle, and acceleration of epidermal regeneration. Restores damaged epidermal areas, improves barrier function, and accelerates metabolic and recovery processes in the skin.
Palmitoyl Tetrapeptide-7
EFFECTS:
- Increases elasticity and density of the dermal matrix, reducing signs of skin laxity.
- Effectively suppresses chronic inflammation and protects against oxidative stress.
- Stimulates cellular regeneration, enhancing skin renewal processes.
- Prevents premature aging, restoring smoothness, firmness, and a refreshed, lifted appearance.
Copper Tripeptide-1
EFFECTS:
- Activates genetic pathways of rejuvenation and regeneration, supporting deep skin renewal.
- Stimulates the formation of new capillaries, improving oxygen and nutrient delivery to the skin.
- Effectively protects and repairs damaged skin cell DNA.
- Suppresses chronic inflammation and glycation, slowing aging processes.
Hexapeptide-11
EFFECTS:
- Strengthens the skin’s basement membrane, restoring density and structural integrity.
- Restores intercellular connections and communication, improving skin structure and appearance.
- Significantly increases firmness and elasticity, reducing signs of laxity.
- Provides a pronounced lifting effect, restoring tautness, smoothness, and youthful definition.
PEPTIDE GROWTH FACTORS COMPLEX
(Oligopeptide-1, -2, -3)
EFFECTS:
- Intensively stimulates skin cell renewal and regeneration.
- Restores damaged areas of the epidermis and improves its structure.
- Strengthens protective (barrier) functions, increasing resistance to external stressors.
- Accelerates metabolic and recovery processes, restoring smoothness, firmness, and a healthy appearance.
WHY DOES CONVENTIONAL SKINCARE FAIL DURING HORMONAL AGING?
Hormonal deficiency, decreased dermal density, and impaired microcirculation. Estrogen deficiency slows cellular metabolism, reduces tissue oxygenation and nourishment, decreases collagen and elastin synthesis, leading to sagging, wrinkles, pigmentation, inflammation, and oxidative stress.
Hormonal deficiency, decreased dermal density, and impaired microcirculation. Estrogen deficiency slows cellular metabolism, reduces tissue oxygenation and nourishment, decreases collagen and elastin synthesis, leading to sagging, wrinkles, pigmentation, inflammation, and oxidative stress.
Our cream combats hormonal aging through a high concentration of precisely selected actives that address the root causes of age-related skin changes:
• Red clover extract compensates for estrogen decline.
• Copper Tripeptide-1 stimulates collagen, elastin, and GAG synthesis.
• Palmitoyl Tetrapeptide-7 reduces pro-inflammatory cytokines.
• Palmitoyl Tripeptide-1 activates fibroblasts and dermal density.
• Oligopeptide-68 corrects pigmentation at the genetic level.
• Hexapeptide-11 reinforces skin structure and elasticity.
• Growth factor peptide complex accelerates epidermal renewal and restores youthful skin architecture.
• Red clover extract compensates for estrogen decline.
• Copper Tripeptide-1 stimulates collagen, elastin, and GAG synthesis.
• Palmitoyl Tetrapeptide-7 reduces pro-inflammatory cytokines.
• Palmitoyl Tripeptide-1 activates fibroblasts and dermal density.
• Oligopeptide-68 corrects pigmentation at the genetic level.
• Hexapeptide-11 reinforces skin structure and elasticity.
• Growth factor peptide complex accelerates epidermal renewal and restores youthful skin architecture.
Our cream combats hormonal aging through a high concentration of precisely selected actives that address the root causes of age-related skin changes:
• Red clover extract compensates for estrogen decline.
• Copper Tripeptide-1 stimulates collagen, elastin, and GAG synthesis.
• Palmitoyl Tetrapeptide-7 reduces pro-inflammatory cytokines.
• Palmitoyl Tripeptide-1 activates fibroblasts and dermal density.
• Oligopeptide-68 corrects pigmentation at the genetic level.
• Hexapeptide-11 reinforces skin structure and elasticity.
• Growth factor peptide complex accelerates epidermal renewal and restores youthful skin architecture.
• Red clover extract compensates for estrogen decline.
• Copper Tripeptide-1 stimulates collagen, elastin, and GAG synthesis.
• Palmitoyl Tetrapeptide-7 reduces pro-inflammatory cytokines.
• Palmitoyl Tripeptide-1 activates fibroblasts and dermal density.
• Oligopeptide-68 corrects pigmentation at the genetic level.
• Hexapeptide-11 reinforces skin structure and elasticity.
• Growth factor peptide complex accelerates epidermal renewal and restores youthful skin architecture.
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